The Importance of Inhibiting the MicrocomedoEither topical or systemic retinoids can normalize keratinization within the follicle, and thus prevent the cohesion of follicular cells that leads to the formation of a microcomedo.Without intervention, the microcomedo may proceed either on a noninflammatory pathway to form mature comedones. Open comedones (blackheads) or closed comedones (whiteheads) - or on an inflammatory pathway to form papules, pustules, and nodules.
With regard to topical acne creams, Vitamin A (retinol) can be effective, although a proportion of the population contract dry and flaking skin when they use it. In fact that is how it works: by promoting flaking off of the top skin cell. It is basically a topical form of the oral isotretinoin, but not as strong. It is not the perfect treatment, and like most acne treatments, it will suit some more than others.
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